TUESDAY, Sept. 20, 2022 (HealthDay News) — Noninvasive excitatory brain stimulation (NIBS) interventions on the left dorsolateral prefrontal cortex are associated with improved severity of negative symptoms of schizophrenia, according to a systematic review and meta- network analysis published online June 22 in JAMA Psychiatry.
Ping-Tao Tseng, MD, Ph.D., of Asia University in Taichung, Taiwan, and colleagues compared the effectiveness and acceptability of different NIBS interventions for treating negative symptoms in participants with of schizophrenia. Data were included from 48 randomized clinical trials (RCTs) with 2211 participants.
The researchers found that excitatory NIBS strategies on the left dorsolateral prefrontal cortex with or without other protocols of inhibitory stimulation in contralateral brain regions were associated with significantly greater reductions in negative symptoms compared to sham control interventions (mean differences standardized, -2.19 for -definition transcranial random noise stimulation; -1.32 for intermittent theta burst stimulation; -1.28 for transcranial direct current anodic stimulation; -0.43 for transcranial magnetic stimulation repetitive at high frequency [rTMS]; and −0.45 for extreme high frequency rTMS). There was no significant difference between the groups observed in acceptability.
“Our results could serve as a starting point for future large-scale RCTs with longer follow-up periods and a sham control to investigate the association between NIBS and negative symptoms of schizophrenia,” the authors write.
One author disclosed financial ties to the pharmaceutical industry.